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RECENT PUBLICATIONS |
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JARID2 regulates binding of the Polycomb repressive complex 2 to target genes in ES cells. Pasini D, Cloos PA, Walfridsson J, Olsson L, Bukowski JP, Johansen JV, Bak M, Tommerup N, Rappsilber J, Helin K. Nature January 2010 |
A functional link between the histo-ne demethylase PHF8 and the tran-scription factor ZNF711 in X-linked mental retardation. Kleine-Kohlbre-cher D, Christensen J, Vandamme J, Abarrategui I, Bak M, Tommerup N, Shi X, Gozani O, Rappsilber J, Salcini AE and Helin K. In Molecular Cell March 24 |
VACANT POSITIONS |
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Two PhD Fellowships in Biomolecular Sciences and Mass Spectrometry: The role of histone modifications in epigenetic regulation
Closing date: June 1 |
A PhD Mobility Fellowship: Functional Analysis of Chromatin Binding Protein Complexes Using Integrated Omics Approaches.
Closing date: Jun 14
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ABOUT US |
More than 50 researchers and 10 technicians are attached to Centre for Epigenetics. Its five research groups are based in Copenhagen and Odense. The groups are working with epigenetics from different angles and perspektives.
The five group leaders are:
- Kristian Helin
- Anders H. Lund
- Ole Nørregaard Jensen
- Morten Frödin
- Klaus Hansen |
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Welcome to
Centre for Epigenetics
The Centre for Epigenetics was established
in the spring 2007 as a Centre of Excellence funded
by The Danish National Research Foundation.
The Centre brings together the distinct expertise of five
research groups with the aim of unveiling basal mechanisms
of epigenetic gene regulation fundamental to all eukaryotic
organisms.
Central to the research is the histone code-hypothesis
and the protein complexes that write, translate and erase
the code. What are their biological and biochemical functions,
and what role do they play in the normal development and
disease?
Professor Kristian Helin (BRIC) is the director
of the centre, which consists of four research groups – four
of them are located at BRIC, University of Copenhagen, and
one at Department of Biochemistry and Molecular Biology, University of Southern Denmark |
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EPIGENETICS on YOUTUBE |
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NEWS |
Researchers from the centre show a functional link between genes invol-ved in X-linked mental retardation affecting around 1 out of 600 men worldwide. Read the press release.. |
In GEN (Feb 2010) you can read about how findings in epigenetics could transform our understanding of cancer biology and get insigt of how some the field's most outstanding researchers, including Kristian Helin, view the impact of their findings.
Read the article: Insights Accrue on Epigenetc Modification |
Researchers from the Centre for Epigenetics and BRIC publishes article on their significant findings on the regulation of embryonic stem cell differentiation in Nature, January 2010. |
The results demonstrate that the Jumonji- and ARID-domain-containing protein JARID2 is essential for the binding of the Polycomb Group (PcG) proteins to target genes and,
consistent with this, for the proper differentiation of embryonic stem cells and normal development and differentiation |
LINKS |
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WHAT'S EPIGENETICS? |
Put shortly, epigenetics is defined as hereditary traits
that are not dependent on changes in the DNA sequence.
Here
is a little longer explanation… |
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Please contact the
centre at: Centre for Epigenetics /BRIC,
Ole Maaløes Vej 5, 4TH, DK-2200 Copenhagen
Tlf: +45 3532 5606
or further information about the centre, please contact administrator and PA Charlotte Hansen, charlotte.hansen@bric.ku.dk
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